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Review
. 2015 Dec 10;339(2):252-60.
doi: 10.1016/j.yexcr.2015.09.015. Epub 2015 Sep 25.

Progress on the relationship between miR-125 family and tumorigenesis

Hang Yin  1 , Yuqiang Sun  2 , Xiaofeng Wang  2 , Jeiyoun Park  3 , Yuanyang Zhang  4 , Molin Li  5 , Jian Yin  2 , Qiang Liu  6 , Minghai Wei  7
Affiliations
Review

Progress on the relationship between miR-125 family and tumorigenesis

Hang Yin et al. Exp Cell Res. .

Abstract

miRNA-125 family, which is a highly conserved miRNA family throughout evolution, is consist of miRNA-125a-3p, miRNA-125a-5p, miRNA-125b-1 and miRNA-125b-2.The aberrant expression of miR-125 familyis tightly related to tumorigenesis and tumor development. The downstream targets of miRNA-125 include transcription factors like STAT3, cytokines like IL-6 and TGF-β, tumor suppressing protein p53, pro-apoptotic protein Bak1 and RNA binding protein HuR et al. Through regulating these downstream targets miR-125 family is involved in regulating tumorigenesis and tumor development. Nowadays, miR-125b have already became a putative and valuable biomarker for cancer diagnosis, treatment and prognosis. In this review, we mainly summarize the dual function of miRNA-125 family in suppression and promotion of cancer cells and further elaborate its regulatory mechanisms from four facets, proliferation, apoptosis, invasion or metastasis and immune response.

Keywords: MiR-125 family; Regulatory mechanism; Target genes; Tumor.

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