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Comment
. 2016 Jan;12(1):245-8.
doi: 10.1016/j.nano.2015.09.005. Epub 2015 Sep 25.

Platelet mimicry: The emperor's new clothes?

Seyed Moein Moghimi  1 , Alan Christy Hunter  2 , Dan Peer  3
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Comment

Platelet mimicry: The emperor's new clothes?

Seyed Moein Moghimi et al. Nanomedicine. 2016 Jan.

Abstract

Here we critically examine whether coating of nanoparticles with platelet membranes can truly disguise them against recognition by elements of the innate immune system. We further assess whether the "cloaking technology" can sufficiently equip nanoparticles with platelet-mimicking functionalities to include in vivo targeting of damaged blood vessels and binding to platelet-adhering opportunistic pathogens. We present views for improved, and pharmaceutically viable nanoparticle design strategies.

Keywords: Complement; Innate immunity; Macrophage; Nanoparticles; Platelets.

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  • Nanoparticle biointerfacing by platelet membrane cloaking.
    Hu CM, Fang RH, Wang KC, Luk BT, Thamphiwatana S, Dehaini D, Nguyen P, Angsantikul P, Wen CH, Kroll AV, Carpenter C, Ramesh M, Qu V, Patel SH, Zhu J, Shi W, Hofman FM, Chen TC, Gao W, Zhang K, Chien S, Zhang L. Hu CM, et al. Nature. 2015 Oct 1;526(7571):118-21. doi: 10.1038/nature15373. Epub 2015 Sep 16. Nature. 2015. PMID: 26374997 Free PMC article.

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