A Blueprint to Address Research Gaps in the Development of Biomarkers for Pediatric Tuberculosis

Mark Patrick Nicol¹, Devasena Gnanashanmugam², Renee Browning², Eleanor S Click³, Luis E Cuevas⁴, Anne Detjen⁵, Steve M Graham⁶, Michael Levin⁷, Mamodikoe Makhene², Payam Nahid⁸, Carlos M Perez-Velez⁹, Klaus Reither¹⁰, Rinn Song¹¹, Hans M L Spiegel¹², Carol Worrell², Heather J Zar¹³, Gerhard Walzl¹⁴

Affiliations

¹ Division of Medical Microbiology and Institute for Infectious Diseases and Molecular Medicine, University of Cape Town and National Health Laboratory Service of South Africa.
² National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
³ Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia.
⁴ Department of Clinical Sciences, Liverpool School of Tropical Medicine, United Kingdom.
⁵ International Union Against Tuberculosis and Lung Disease, Paris, France.
⁶ International Union Against Tuberculosis and Lung Disease, Paris, France Centre for International Child Health, University of Melbourne, and Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital Burnet Institute, Melbourne, Australia.
⁷ Department of Pediatrics, Imperial College, London, United Kingdom.
⁸ Pulmonary and Critical Care Medicine, University of California, San Francisco.
⁹ Division of Infectious Diseases, Banner-University Medical Center Phoenix, University of Arizona College of Medicine.
¹⁰ Swiss Tropical and Public Health Institute, University of Basel, Switzerland.
¹¹ Division of Infectious Diseases, Boston Children's Hospital Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
¹² HJF-DAIDS, a Division of The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Contractor to National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
¹³ Department of Paediatrics and Child Health, Red Cross Children's Hospital and Medical Research Council Unit on Child and Adolescent Health, University of Cape Town.
¹⁴ Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research/Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.

PMID: 26409279
PMCID: PMC4583573
DOI: 10.1093/cid/civ613

A Blueprint to Address Research Gaps in the Development of Biomarkers for Pediatric Tuberculosis

Mark Patrick Nicol et al. Clin Infect Dis. 2015.

. 2015 Oct 15;61Suppl 3(Suppl 3):S164-72.

doi: 10.1093/cid/civ613.

Authors

Affiliations

¹ Division of Medical Microbiology and Institute for Infectious Diseases and Molecular Medicine, University of Cape Town and National Health Laboratory Service of South Africa.
² National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
³ Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia.
⁴ Department of Clinical Sciences, Liverpool School of Tropical Medicine, United Kingdom.
⁵ International Union Against Tuberculosis and Lung Disease, Paris, France.
⁶ International Union Against Tuberculosis and Lung Disease, Paris, France Centre for International Child Health, University of Melbourne, and Department of Paediatrics and Murdoch Childrens Research Institute, Royal Children's Hospital Burnet Institute, Melbourne, Australia.
⁷ Department of Pediatrics, Imperial College, London, United Kingdom.
⁸ Pulmonary and Critical Care Medicine, University of California, San Francisco.
⁹ Division of Infectious Diseases, Banner-University Medical Center Phoenix, University of Arizona College of Medicine.
¹⁰ Swiss Tropical and Public Health Institute, University of Basel, Switzerland.
¹¹ Division of Infectious Diseases, Boston Children's Hospital Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
¹² HJF-DAIDS, a Division of The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Contractor to National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
¹³ Department of Paediatrics and Child Health, Red Cross Children's Hospital and Medical Research Council Unit on Child and Adolescent Health, University of Cape Town.
¹⁴ Department of Science and Technology and National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research/Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.

PMID: 26409279
PMCID: PMC4583573
DOI: 10.1093/cid/civ613

Abstract

Childhood tuberculosis contributes significantly to the global tuberculosis disease burden but remains challenging to diagnose due to inadequate methods of pathogen detection in paucibacillary pediatric samples and lack of a child-specific host biomarker to identify disease. Accurately diagnosing tuberculosis in children is required to improve case detection, surveillance, healthcare delivery, and effective advocacy. In May 2014, the National Institutes of Health convened a workshop including researchers in the field to delineate priorities to address this research gap. This blueprint describes the consensus from the workshop, identifies critical research steps to advance this field, and aims to catalyze efforts toward harmonization and collaboration in this area.

Keywords: biomarker; blueprint; children; diagnosis; tuberculosis.

PubMed Disclaimer

References

1. World Health Organization. Global tuberculosis report 2014. Geneva, Switzerland: WHO, 2014:1–289.
1. Dodd PJ, Gardiner E, Coghlan R, Seddon JA. Burden of childhood tuberculosis in 22 high-burden countries: a mathematical modelling study. Lancet Glob Health 2014; 2:e453–9. - PubMed
1. Graham SM, Sismanidis C, Menzies HJ, Marais BJ, Detjen AK, Black RE. Importance of tuberculosis control to address child survival. Lancet 2014; 383:1605–7. - PMC - PubMed
1. Swingler GH, du Toit G, Andronikou S, van der Merwe L, Zar HJ. Diagnostic accuracy of chest radiography in detecting mediastinal lymphadenopathy in suspected pulmonary tuberculosis. Arch Dis Child 2005; 90:1153–6. - PMC - PubMed
1. Hatherill M, Hanslo M, Hawkridge T, et al. Structured approaches for the screening and diagnosis of childhood tuberculosis in a high prevalence region of South Africa. Bull World Health Organ 2010; 88:312–20. - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

A Blueprint to Address Research Gaps in the Development of Biomarkers for Pediatric Tuberculosis

Affiliations

A Blueprint to Address Research Gaps in the Development of Biomarkers for Pediatric Tuberculosis

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Miscellaneous