Investigation of orbitofrontal sulcogyral pattern in chronic schizophrenia

Vanessa L Cropley¹, Cali F Bartholomeusz², Peter Wu³, Stephen J Wood⁴, Tina Proffitt⁵, Warrick J Brewer⁶, Patricia M Desmond⁷, Dennis Velakoulis³, Christos Pantelis⁸

Affiliations

¹ Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia. Electronic address: vcropley@unimelb.edu.au.
² Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia; Orygen, The National Centre of Excellence in Youth Mental Health, The University of Melbourne and Melbourne Health, Parkville, Victoria 3052, Australia.
³ Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia.
⁴ Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia; School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
⁵ Orygen, The National Centre of Excellence in Youth Mental Health, The University of Melbourne and Melbourne Health, Parkville, Victoria 3052, Australia.
⁶ Orygen, The National Centre of Excellence in Youth Mental Health, The University of Melbourne and Melbourne Health, Parkville, Victoria 3052, Australia; Department of Psychiatry, The University of Melbourne, Parkville, Victoria 3052, Australia.
⁷ Department of Medicine and Radiology, The University of Melbourne, Royal Melbourne Hospital, Carlton South, Victoria 3053, Australia.
⁸ Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia; Department of Psychiatry, The University of Melbourne, Parkville, Victoria 3052, Australia.

PMID: 26409572
DOI: 10.1016/j.pscychresns.2015.09.001

Investigation of orbitofrontal sulcogyral pattern in chronic schizophrenia

Vanessa L Cropley et al. Psychiatry Res. 2015.

. 2015 Nov 30;234(2):280-3.

doi: 10.1016/j.pscychresns.2015.09.001. Epub 2015 Sep 5.

Authors

Vanessa L Cropley¹, Cali F Bartholomeusz², Peter Wu³, Stephen J Wood⁴, Tina Proffitt⁵, Warrick J Brewer⁶, Patricia M Desmond⁷, Dennis Velakoulis³, Christos Pantelis⁸

Affiliations

¹ Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia. Electronic address: vcropley@unimelb.edu.au.
² Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia; Orygen, The National Centre of Excellence in Youth Mental Health, The University of Melbourne and Melbourne Health, Parkville, Victoria 3052, Australia.
³ Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia.
⁴ Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia; School of Psychology, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
⁵ Orygen, The National Centre of Excellence in Youth Mental Health, The University of Melbourne and Melbourne Health, Parkville, Victoria 3052, Australia.
⁶ Orygen, The National Centre of Excellence in Youth Mental Health, The University of Melbourne and Melbourne Health, Parkville, Victoria 3052, Australia; Department of Psychiatry, The University of Melbourne, Parkville, Victoria 3052, Australia.
⁷ Department of Medicine and Radiology, The University of Melbourne, Royal Melbourne Hospital, Carlton South, Victoria 3053, Australia.
⁸ Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia; Department of Psychiatry, The University of Melbourne, Parkville, Victoria 3052, Australia.

PMID: 26409572
DOI: 10.1016/j.pscychresns.2015.09.001

Abstract

Abnormalities of orbitofrontal cortex (OFC) pattern type distribution have been associated with schizophrenia-spectrum disorders. We investigated OFC pattern type in a large sample of chronic schizophrenia patients and healthy controls. We found an increased frequency of Type II but no difference in Type I or III folding pattern in the schizophrenia group in comparison to controls. Further large studies are required to investigate the diagnostic specificity of altered OFC pattern type and to confirm the distribution of pattern type in the normal population.

Keywords: Orbitofrontal cortex; Pattern type; Schizophrenia.

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Investigation of orbitofrontal sulcogyral pattern in chronic schizophrenia

Affiliations

Investigation of orbitofrontal sulcogyral pattern in chronic schizophrenia

Authors

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Abstract

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