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Review
. 2015 Oct;31(4):661-74.
doi: 10.1016/j.ccc.2015.06.004. Epub 2015 Aug 7.

Thrombocytopenia-Associated Multiple Organ Failure and Acute Kidney Injury

Trung C Nguyen  1 , Miguel A Cruz  2 , Joseph A Carcillo  3
Affiliations
Review

Thrombocytopenia-Associated Multiple Organ Failure and Acute Kidney Injury

Trung C Nguyen et al. Crit Care Clin. 2015 Oct.

Abstract

Thrombocytopenia-associated multiple organ failure (TAMOF) is a clinical phenotype that encompasses a spectrum of syndromes associated with disseminated microvascular thromboses, such as the thrombotic microangiopathies thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) and disseminated intravascular coagulation (DIC). Autopsies findings in TTP, HUS, or DIC reveal specific findings that can differentiate these 3 entities. Von Willebrand factor and ADAMTS-13 play a central role in TTP. Shiga toxins and the complement pathway are vital in the development of HUS. Tissue factor is the major protease that drives the pathology of DIC. Acute kidney injury (AKI) is a common feature in patients with TAMOF.

Keywords: ADAMTS-13; AKI; DIC; HUS; Platelet; TAMOF; TTP; VWF.

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References

    1. Hosler GA, Cusumano AM, Hutchins GM. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are distinct pathologic entities. A review of 56 autopsy cases. Arch Pathol Lab Med. 2003;127(7):834–9. - PubMed
    1. Burke AP, Mont E, Kolodgie F, et al. Thrombotic thrombocytopenic purpura causing rapid unexpected death: value of CD61 immunohistochemical staining in diagnosis. Cardiovasc Pathol. 2005;14(3):150–5. - PubMed
    1. Kojima M, Shimamura K, Mori N, et al. A histological study on microthrombi in autopsy cases of DIC. Bibl Haematol. 1983;(49):95–106. - PubMed
    1. Asada Y, Sumiyoshi A, Hayashi T, et al. Immunohistochemistry of vascular lesion in thrombotic thrombocytopenic purpura, with special reference to factor VIII related antigen. Thromb Res. 1985;38(5):469–79. - PubMed
    1. Dhainaut JF, Yan SB, Joyce DE, et al. Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation. J Thromb Haemost. 2004;2(11):1924–33. - PubMed

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