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Review
. 2015 Oct;46(4):577-85.
doi: 10.1016/j.ocl.2015.06.008.

Paget Disease of Bone

Mamun Al-Rashid  1 , Dipak B Ramkumar  2 , Kevin Raskin  3 , Joseph Schwab  3 , Francis J Hornicek  3 , Santiago A Lozano-Calderón  4
Affiliations
Review

Paget Disease of Bone

Mamun Al-Rashid et al. Orthop Clin North Am. 2015 Oct.

Abstract

The current understanding of Paget disease of bone (PDB) has vastly changed since Paget described the first case in 1877. Medical management of this condition remains the mainstay of treatment. Surgical intervention is usually only used in fractures through pagetic bone, need for realignment to correct deformity in major long bones, prophylactic treatment of impending fractures, joint arthroplasty in severe arthritis, or spinal decompression in cases of bony compression of neural elements. Advances in surgical technique have allowed early return to function and mobilization. Despite medical and surgical intervention, a small subset of patients with PDB develops Paget sarcoma.

Keywords: Arthroplasty in Paget disease; Bisphosphonates; Bone turnover; Fracture fixation of pagetic bone; Paget; Paget disease of bone; Paget sarcoma; SQSTM1.

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