Mucinous Adenocarcinoma of the Male Urethra: A Report of Two Cases

Abstract

Background: Primary malignancies arising in the urethra are rare and, contrary to the other genitourinary malignancies, are more common in female patients. The pathologic diagnosis of primary adenocarcinoma can be challenging due to its rarity and overlapping features with other primary and secondary malignancies. There is no specific immunoprofile to define these adenocarcinomas, but available markers may allow comparison with common secondary tumors. About 30 primary cases have been recorded to date.

Cases: We report 2 cases of primary mucinous adenocarcinoma of the male urethra, one with possible origin from Littrè glands and the other from the prostatic urethra.

Conclusion: The available data suggest that this is a heterogeneous group of aggressive tumors and that the optimal management remains to be established.