High mobility group (HMG) proteins: Modulators of chromatin structure and DNA repair in mammalian cells

Abstract

It has been almost a decade since the last review appeared comparing and contrasting the influences that the different families of High Mobility Group proteins (HMGA, HMGB and HMGN) have on the various DNA repair pathways in mammalian cells. During that time considerable progress has been made in our understanding of how these non-histone proteins modulate the efficiency of DNA repair by all of the major cellular pathways: nucleotide excision repair, base excision repair, double-stand break repair and mismatch repair. Although there are often similar and over-lapping biological activities shared by all HMG proteins, members of each of the different families appear to have a somewhat 'individualistic' impact on various DNA repair pathways. This review will focus on what is currently known about the roles that different HMG proteins play in DNA repair processes and discuss possible future research areas in this rapidly evolving field.

Keywords: Base excision repair (BER); Chromatin remodeling; Double-strand break repair (DSBR); HMGA; HMGB; HMGN; Mismatch repair (MMR); Nucleotide excision repair (NER).