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Review
. 2015 Oct;102(10):880-8.
doi: 10.1016/j.bulcan.2015.07.005. Epub 2015 Sep 26.

Primary signet ring cell carcinoma of the colon and rectum

Samia Arifi  1 , Omar Elmesbahi  2 , Afaf Amarti Riffi  3
Affiliations
Review

Primary signet ring cell carcinoma of the colon and rectum

Samia Arifi et al. Bull Cancer. 2015 Oct.

Abstract

Colorectal primary signet ring cell carcinoma (SRCC) is a rare entity accounting for nearly 1% of all colorectal carcinomas. It is an independent prognostic factor associated with less favorable outcome. This aggressiveness is mainly due to the intrinsic biology of these tumors. Here is an overview of the literature related to clinicopathological features, molecular biology, and management of SRCC of the colon and the rectum.

Keywords: Colorectal cancer; Molecular biology; Pathology; Signet ring cell; Treatment.

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