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Review
. 2015 Nov;27(4):489-96.
doi: 10.1016/j.coms.2015.06.001. Epub 2015 Sep 26.

Pathophysiology of Osteonecrosis of the Jaws

Tara Aghaloo  1 , Renna Hazboun  2 , Sotirios Tetradis  3
Affiliations
Review

Pathophysiology of Osteonecrosis of the Jaws

Tara Aghaloo et al. Oral Maxillofac Surg Clin North Am. 2015 Nov.

Abstract

Osteonecrosis of the jaw (ONJ) is a multifactorial disease in patients with primary or metastatic bone malignancy or osteoporosis undergoing systemic antiresorptive therapy, where pathophysiology has not yet been fully determined. The staging of ONJ is based on severity of symptoms and extent of clinical and radiographic findings. Treatment strategies range from conservative local wound care to aggressive resective surgery of all necrotic bone. The first ONJ cases were reported in 2003 and 2004, and although significant progress has been made in our understanding of the disease, much more work needs to be done to completely explain its pathophysiology.

Keywords: Antiresorptive; Bisphosphonates; MRONJ; Osteonecrosis of the jaws (ONJ); Pathophysiology.

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Figures

Figure 1
Figure 1
The potential synergy of multiple pathways of ONJ
See this image and copyright information in PMC

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