Membrane-Introduction Mass Spectrometry Analysis of Desflurane, Propofol and Fentanyl in Plasma and Cerebrospinal Fluid for Estimation BBB Properties
- PMID: 26412969
- PMCID: PMC4580747
- DOI: 10.5607/en.2015.24.3.206
Membrane-Introduction Mass Spectrometry Analysis of Desflurane, Propofol and Fentanyl in Plasma and Cerebrospinal Fluid for Estimation BBB Properties
Abstract
A possibility to use the Membrane-Introduction Mass Spectrometry (MIMS) with membrane separator interface has evolved into a powerful method for measurement of anaesthetic agents absolute concentration in blood plasma and cerebrospinal fluid for the study of blood-brain barrier (BBB) properties. Recent advanced a new membrane material was used for drug concentration measurement in biologic fluids. A hydrophobic membrane was used in the interface to separate anaesthetic agents from biological fluids: inhalational anaesthetic desflurane,hypnotic propofol, analgesic fentanyl. The selective detection of volatile anesthetic agents in blood does not require long-term sample processing before injecting the sample into mass-spectrometer interface, in contrast to chromatographic methods. Mass-spectrometric interface for the measurement of anaesthetic agent concentration in biological fluids (blood plasma and cerebrospinal fluid) is described. Sampling of biological fluids was performed during balanced inhalational (desflurane, fentanyl) anaesthesia and total intravenous (propofol, fentanyl) anaesthesia.
Keywords: anesthesia; desflurane; fentanyl; mass-spectrometer; membrane.
Figures





References
-
- Ojala M, Mattila I, Särme T, Ketola RA, Kotiaho T. A new purge-and-membrane mass spectrometric (PAM-MS) instrument for analysis of volatile organic compounds in soil samples. Analyst. 1999;124:1421–1424.
-
- Johnson RC, Cooks RG, Allen TM, Cisper ME, Hemberger PH. Membrane introduction mass spectrometry: trends and applications. Mass Spectrom Rev. 2000;19:1–37. - PubMed
-
- Saracco G, Neomagus HW, Versteeg GF, van Swaaij WP. High-temperature membrane reactors: potential and problems. Chem Eng Sci. 1999;54:1997–2017.
-
- Bolto B, Hoang M, Xie ZL. A review of membrane selection for the dehydration of aqueous ethanol by pervaporation. Chem Eng Process. 2011;50:227–235.
LinkOut - more resources
Full Text Sources
Other Literature Sources