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. 2015 Fall;15(3):272-6.

Role of Special Coagulation Studies for Preoperative Screening of Thrombotic Complications in Simultaneous Pancreas-Kidney Transplantation

Abdul Moiz  1 , Tariq Javed  2 , Humberto Bohorquez  3 , David S Bruce  3 , Ian C Carmody  3 , Ari J Cohen  3 , Catherine Staffeld-Coit  4 , Qingyang Luo  5 , George E Loss Jr  3 , Jorge Garces  4
Affiliations

Role of Special Coagulation Studies for Preoperative Screening of Thrombotic Complications in Simultaneous Pancreas-Kidney Transplantation

Abdul Moiz et al. Ochsner J. 2015 Fall.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Ochsner J. 2016 Spring;16(1):5. Ochsner J. 2016. PMID: 27026783 Free PMC article.

Abstract

Background: Vascular thrombosis is a well-known complication after simultaneous pancreas-kidney (SPK) transplantation procedures. The role of preoperative special coagulation studies to screen patients at high risk for vascular thrombosis is unclear and not well studied.

Methods: This study reports a retrospective medical record review of 83 SPK procedures performed between April 2007 and June 2013 in a single institution. All SPK transplantation recipients underwent preoperative screening for hypercoagulable state.

Results: Eighteen of 83 patients (21.69%) were diagnosed with vascular thrombosis of the pancreas. Of the 23 patients with at least 1 positive screening test, only 4 had a thrombotic event (17.39%). On the other hand, 14 of 60 patients with negative screening tests developed vascular thrombosis (23.33%). The hypercoagulable screening workup had a positive predictive value of 17.39% and a negative predictive value of 76.67%. The workup also demonstrated low sensitivity (22.22%) and specificity (70.77%).

Conclusion: No differences were seen in patient or graft survival between groups at 12 months. This retrospective study did not show any benefit of using special coagulation studies to rule out patients at risk for vascular thrombosis after SPK transplantation.

Keywords: Blood coagulation tests; kidney transplantation; mesenteric ischemia; organ transplantation; pancreas transplantation; thrombosis.

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Figures

Figure.
Figure.
Schematic illustration of the study.
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