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Review
. 2015 Sep 26;5(3):149-56.
doi: 10.5662/wjm.v5.i3.149.

Refractory chronic cough due to gastroesophageal reflux: Definition, mechanism and management

Han-Jing Lv  1 , Zhong-Min Qiu  1
Affiliations
Review

Refractory chronic cough due to gastroesophageal reflux: Definition, mechanism and management

Han-Jing Lv et al. World J Methodol. .

Abstract

Refractory chronic cough due to gastroesophageal reflux is a troublesome condition unresponsive to the standard medical anti-reflux therapy. Its underlying mechanisms may include incomplete acid suppression, non-acid reflux, transient lower esophageal sphincter relaxations and esophageal hypersensitivity. The diagnosis of this disorder depends on both the findings of multi-channel intraluminal impedance-pH monitoring and the subsequent intensified anti-reflux therapy. The strategies of pharmacological treatment for refractory chronic cough due to reflux include the optimization of proton pump inhibitors and add-on therapies with histamine H2 receptor antagonists, baclofen and gabapentin. However, the further study is needed to satisfy its management.

Keywords: Anti-reflux therapy; Chronic cough; Esophageal pH monitoring; Gastroesophageal reflux; Refractory cough.

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Figure 1
Figure 1
Diagnostic algorithm for refractory chronic cough due to reflux.
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