Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Sep 26;5(3):164-74.
doi: 10.5662/wjm.v5.i3.164.

Prevalence of antibiotic resistance in Helicobacter pylori: A recent literature review

Reza Ghotaslou  1 , Hamed Ebrahimzadeh Leylabadlo  1 , Yalda Mohammadzadeh Asl  1
Affiliations
Review

Prevalence of antibiotic resistance in Helicobacter pylori: A recent literature review

Reza Ghotaslou et al. World J Methodol. .

Abstract

Aim: To review previous studies (the last 6 years) about the Helicobacter pylori (H. pylori) antibiotic resistance in order to evaluate the trend in antibiotic resistance.

Methods: In this study, the PubMed, MEDLINE, Science Direct, Google Scholar and Scielo manuscripts were reviewed from 2009 to 2014.

Results: On the whole rates of H. pylori antibiotic resistance were 47.22% (30.5%-75.02%) for metronidazole, 19.74% (5.46%-30.8%) for clarithromycin, 18.94% (14.19%-25.28%) for levofloxacin, and 14.67% (2%-40.87%) for amoxicillin, 11.70% (0%-50%) for tetracycline, 11.5% (0%-23%) for furazolidon and 6.75% (1%-12.45%) for rifabutin. The frequency of tetracycline, metronidazole and amoxicillin resistance was higher in Africa, while clarithromycin and levofloxacin resistance was higher in North America and Asian, respectively.

Conclusion: The most sensitive drug is rifabutin and the lowest sensitive drug is metronidazole in the world. The worldwide H. pylori antibiotic resistance to clarithromycin and levofloxacin has increased during the last 6 years. The present systematic review show alarming results and a novel plan is needed for eradication therapy of H. pylori infections.

Keywords: Antibiotic resistance; Helicobacter pylori; Worldwide.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Antibiotic resistance rates to 4 most common used antibiotics in different continental areas.
Figure 2
Figure 2
Trend of Helicobacter pylori resistance to metronidazole, clarithromycin, and amoxicillin during 6-years.
See this image and copyright information in PMC

References

    1. Rafeey M, Ghotaslou R, Nikvash S, Hafez AA. Primary resistance in Helicobacter pylori isolated in children from Iran. J Infect Chemother. 2007;13:291–295. - PubMed
    1. Ghotaslou R, Milani M, Akhi MT, Hejazi MS, Nahaei MR, Hasani A, Sharifi Y. Relationship between drug resistance and cagA Gene in Helicobacter pylori. Jundishapur J Microbiol. 2013;6:8480.
    1. Ghotaslou R, Milani M, Akhi MT, Nahaei MR, Hasani A, Hejazi MS, Meshkini M. Diversity of Helicobacter Pylori cagA and vacA Genes and Its Relationship with Clinical Outcomes in Azerbaijan, Iran. Adv Pharm Bull. 2013;3:57–62. - PMC - PubMed
    1. Gasbarrini G, Racco S, Franceschi F, Miele L, Cammarota G, Grieco A, Gasbarrini A. [Helicobacter pylori infection: from gastric to systemic disease] Recenti Prog Med. 2010;101:27–33. - PubMed
    1. Malfertheiner P, Megraud F, O’Morain C, Bazzoli F, El-Omar E, Graham D, Hunt R, Rokkas T, Vakil N, Kuipers EJ. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut. 2007;56:772–781. - PMC - PubMed