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. 2015 Nov;40(3):704-7.
doi: 10.1016/j.etap.2015.09.001. Epub 2015 Sep 8.

Effects of waterborne fluoxetine on stress response and osmoregulation in zebrafish

Murilo S Abreu  1 , Ana Cristina V Giacomini  2 , Gessi Koakoski  3 , Thiago A Oliveira  4 , Darlan Gusso  5 , Bernardo Baldisserotto  6 , Leonardo J G Barcellos  7
Affiliations

Effects of waterborne fluoxetine on stress response and osmoregulation in zebrafish

Murilo S Abreu et al. Environ Toxicol Pharmacol. 2015 Nov.

Abstract

The presence of fluoxetine in aquatic environments has been reported for decades. Here, we investigate the effects of exposure to fluoxetine on the stress response and osmoregulation in zebrafish. We show that stress response alters osmoregulation and that fluoxetine inhibits these stress-related changes in osmoregulation. The results suggest that the presence of fluoxetine in aquatic ecosystems can cause changes in response to stress and osmoregulation in fish.

Keywords: Cortisol; Danio rerio; Homeostasis; Osmoregulation; Psychotropic drug; SSRI.

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