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. 2016 Aug;16(3):463-70.
doi: 10.1007/s10238-015-0377-y. Epub 2015 Sep 28.

HFE p.C282Y gene variant is associated with varicose veins in Russian population

Ekaterina A Sokolova  1   2 , Alexandra S Shadrina  1   2 , Kseniya S Sevost'ianova  1 , Andrey I Shevela  1 , Evgenii Yu Soldatsky  3 , Evgenii I Seliverstov  3 , Marina Yu Demekhova  4 , Oleg A Shonov  4 , Evgenii A Ilyukhin  4 , Mariya A Smetanina  1 , Elena N Voronina  1   2 , Igor A Zolotukhin  3 , Maxim L Filipenko  5   6
Affiliations

HFE p.C282Y gene variant is associated with varicose veins in Russian population

Ekaterina A Sokolova et al. Clin Exp Med. 2016 Aug.

Abstract

Recently, the association of polymorphism rs1800562 (p.C282Y) in the hemochromatosis (HFE) gene with the increased risk of venous ulceration was shown. We hypothesized that HFE gene polymorphism might be involved not only in ulceration process, but also in susceptibility to primary varicose veins. We genotyped HFE p.C282Y (rs1800562) and p.H63D (rs1799945) variants in patients with primary varicose veins (n = 463) and in the control group (n = 754). In our study, p.282Y variant (rs1800562 A allele) was significantly associated with the risk of varicose veins (OR 1.79, 95 % CI = 1.11-2.89, P = 0.02). A borderline significant reverse association of p.63D variant (rs1799945 G allele) with venous leg ulcer development was revealed in Russians (OR 0.25, 95 % CI = 0.06-1.00, P = 0.05), but not in the meta-analysis (P = 0.56). We conclude that the HFE gene polymorphism can affect the risk of developing primary varicose veins.

Keywords: Hemochromatosis gene; Primary varicose veins.

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