Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Sep 28:10:33.
doi: 10.1186/s13027-015-0027-8. eCollection 2015.

Human papillomavirus types in non-cervical high-grade intraepithelial neoplasias and invasive carcinomas from San Luis Potosí, Mexico: a retrospective cross-sectional study

Claudia Magaña-León  1 , Cuauhtémoc Oros  2 , Rubén López-Revilla  1
Affiliations

Human papillomavirus types in non-cervical high-grade intraepithelial neoplasias and invasive carcinomas from San Luis Potosí, Mexico: a retrospective cross-sectional study

Claudia Magaña-León et al. Infect Agent Cancer. .

Erratum in

Abstract

Background: Viral infections and the burden of high-grade intraepithelial neoplasias (HIN) and invasive carcinomas (IC) associated to infections by human papillomavirus (HPV) types may be prevented by type-specific anti-HPV vaccines. This study determined the prevalence of HPV types in non-cervical HIN and IC diagnosed from 1999 to 2011 at a general hospital in San Luis Potosí, Mexico.

Methods: Review of the 67 formaldehyde-fixed paraffin-embedded non-cervical specimens initially diagnosed as HIN (n = 28) or IC (n = 39) confirmed the presence of tumor tissue in 63 of them and changed the diagnosis of 24 from HIN to low-grade intraepithelial neoplasias, that were excluded from the study. HPV DNA was detected with the SPF10-DNA enzyme immunoassay in the 39 cases included, and viral types in the HPV-positive tumors were identified with the INNO-LiPA linear probe array.

Results: Among the cases included, four HIN were located in the vagina (n = 3) and vulva (n = 1), and 35 IC in the oral cavity (n = 19), penis (n = 8), vagina (n = 7) and vulva (n = 1). There were 13 HPV-positive cases from the vagina (n = 7), vulva (n = 1), penis (n = 1) and oral cavity (n = 1). The viral types identified were the high-risk types HPV16 in the vagina (n = 3) and vulva (n = 3), HPV45 in the vagina (n = 2), HPV59 in the vagina (n = 1) and penis (n = 1), HPV33 in the vagina (n = 1),and HPV35 in the tongue(n = 1); and the low-risk types HPV54 in the vagina (n = 1), and HPV11 in the vulva (n = 1).

Conclusions: Five high-risk viral types (HPV16, 45, 59, 33 and 35) and two low-risk types (HPV11 and 54) infect one third of the non-cervical HIN and IC included. Most infections are by a single HPV high-risk type, the most prevalent one being HPV16. Vagina is the most frequent location of the HPV-positive tumors. Vaccination against HPV16 and HPV18 could have prevented around half of the HPV-positive tumors.

Keywords: HPV; INNO-LiPA; Non-cervical carcinomas; SPF10.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Stages of the study. Histopathological review showed that four of the 67 initial paraffin blocks lacked tumor tissue and were discarded. Of the 63 acceptable paraffin blocks, 28 were excluded because their initial diagnoses changed from HIN to LIN. DNA extracted from the paraffin blocks of the 39 cases included (35 IC and four HIN) was subjected to the SPF10-DEIA assay. The 13 HPV-positive cases were further analyzed with the INNO-LiPA assay to identify the viral types
See this image and copyright information in PMC

References

    1. de Sanjose S, Quint WG, Alemany L, Geraets DT, Klaustermeier JE, Lloveras B, et al. Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. Lancet Oncol. 2010;11(11):1048–56. doi: 10.1016/S1470-2045(10)70230-8. - DOI - PubMed
    1. Illades-Aguiar B, Alarcon-Romero Ldel C, Antonio-Vejar V, Zamudio-Lopez N, Sales-Linares N, Flores-Alfaro E, et al. Prevalence and distribution of human papillomavirus types in cervical cancer, squamous intraepithelial lesions, and with no intraepithelial lesions in women from Southern Mexico. Gynecol Oncol. 2010;117(2):291–6. doi: 10.1016/j.ygyno.2010.01.036. - DOI - PubMed
    1. Lizano M, De la Cruz-Hernandez E, Carrillo-Garcia A, Garcia-Carranca A, de Ponce Leon-Rosales S, Duenas-Gonzalez A, et al. Distribution of HPV16 and 18 intratypic variants in normal cytology, intraepithelial lesions, and cervical cancer in a Mexican population. Gynecol Oncol. 2006;102(2):230–5. doi: 10.1016/j.ygyno.2005.12.002. - DOI - PubMed
    1. Montoya-Fuentes H, Suarez Rincon AE, Ramirez-Munoz MP, Arevalo-Lagunas I, Moran Moguel MC, Gallegos Arreola MP, et al. The detection of human papillomavirus 16, 18, 35 and 58 in cervical-uterine cancer and advanced degree of squamous intraepithelial lesions in Western Mexico: clinical-molecular correlation. Ginecol Obstet Mex. 2001;69:137–42. - PubMed
    1. Lopez-Revilla R, Martinez-Contreras LA, Sanchez-Garza M. Prevalence of high-risk human papillomavirus types in Mexican women with cervical intraepithelial neoplasia and invasive carcinoma. Infect Agent Cancer. 2008;3:3. doi: 10.1186/1750-9378-3-3. - DOI - PMC - PubMed

LinkOut - more resources