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. 2015 Sep;6(5):567-70.
doi: 10.1111/jdi.12340. Epub 2015 Apr 2.

Fear of hypoglycemia and its determinants in insulin-treated patients with type 2 diabetes mellitus

Naoki Sakane  1 , Kazuhiko Kotani  2 , Kokoro Tsuzaki  1 , Masami Nishi  3 , Kaoru Takahashi  4 , Takashi Murata  5 , Kazunori Yamada  5 , Kentaro Okazaki  6 , Katsuyuki Yanagisawa  7 , Kenichi Yamada  8 , Nobuichi Kuribayashi  9 , Yasuo Totsuka  10 , Toru Hiyoshi  11 , Motoji Naka  12 , Masatake Sugimoto  13 , Yuji Aoki  14 , Masako Waki  15 , Miyuki Furuya  16 , Haruko Kitaoka  17 , Mariko Oishi  18 , Ikki Shimizu  19 , Hiroaki Miyaoka  20 , Akira Okada  21 , Toshikazu Yamamoto  22
Affiliations

Fear of hypoglycemia and its determinants in insulin-treated patients with type 2 diabetes mellitus

Naoki Sakane et al. J Diabetes Investig. 2015 Sep.

Abstract

The aim of the present study was to investigate the prevalence of fear of hypoglycemia, in association with severe hypoglycemia and social factors, in insulin-treated patients with type 2 diabetes mellitus. A questionnaire survey on hypoglycemia and patient-physician communication was carried out in 355 patients with insulin-treated type 2 diabetes mellitus patients at 16 hospitals and clinics. A fear of hypoglycemia was reported by 27.7% of patients. A stepwise logistic regression analysis found that severe hypoglycemia during the past 1 year was a significant determinant of fear of hypoglycemia (odds ratio 2.16, 95% confidence interval 1.06-4.41; P = 0.034), and age (odds ratio 1.02, 95% confidence interval 1.00-1.05, P = 0.038) and living alone (odds ratio 1.93, 95% confidence interval 1.00-3.73, P < 0.05) were significantly higher in patients with fear of hypoglycemia than in those without it.

Keywords: Fear; Hypoglycemia; Insulin; Type 2 diabetes.

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