Bedside monitoring of patients with shock using a portable spatially-resolved near-infrared spectroscopy

Ting Li¹, Meixue Duan², Kai Li³, Guoqiang Yu⁴, Zhengshang Ruan⁵

Affiliations

¹ State Key Lab Elect Thin Film & Integrated Device and Department of Biomedical Engineering, University of Electronic Science & Technology of China, Chengdu 610054, China ; These authors contributed equally to this work ; liting@uestc.edu.cn.
² State Key Lab Elect Thin Film & Integrated Device and Department of Biomedical Engineering, University of Electronic Science & Technology of China, Chengdu 610054, China ; These authors contributed equally to this work.
³ State Key Lab Elect Thin Film & Integrated Device and Department of Biomedical Engineering, University of Electronic Science & Technology of China, Chengdu 610054, China.
⁴ Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40506-0108, USA.
⁵ Department of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital, Shanghai 200092, China.

PMID: 26417512
PMCID: PMC4574668
DOI: 10.1364/BOE.6.003431

Bedside monitoring of patients with shock using a portable spatially-resolved near-infrared spectroscopy

Ting Li et al. Biomed Opt Express. 2015.

. 2015 Aug 19;6(9):3431-6.

doi: 10.1364/BOE.6.003431. eCollection 2015 Sep 1.

Authors

Ting Li¹, Meixue Duan², Kai Li³, Guoqiang Yu⁴, Zhengshang Ruan⁵

Affiliations

¹ State Key Lab Elect Thin Film & Integrated Device and Department of Biomedical Engineering, University of Electronic Science & Technology of China, Chengdu 610054, China ; These authors contributed equally to this work ; liting@uestc.edu.cn.
² State Key Lab Elect Thin Film & Integrated Device and Department of Biomedical Engineering, University of Electronic Science & Technology of China, Chengdu 610054, China ; These authors contributed equally to this work.
³ State Key Lab Elect Thin Film & Integrated Device and Department of Biomedical Engineering, University of Electronic Science & Technology of China, Chengdu 610054, China.
⁴ Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40506-0108, USA.
⁵ Department of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital, Shanghai 200092, China.

PMID: 26417512
PMCID: PMC4574668
DOI: 10.1364/BOE.6.003431

Abstract

Clinical monitoring of shock mainly depends on blood-oxygen-indices obtained from invasive blood sample tests. The central internal jugular central vein oxygenation level (ScvO2) has been considered as a gold standard indicator for shock prediction. We developed a noninvasive spatially-resolved near-infrared spectroscopy (SR-NIRS) to measure tissue blood oxygen saturation (StO2) surrounding the region of taking blood sample for the ScvO2 test in 25 patients with shock. StO2 values were found to be highly correlated (r = 0.84, p < 0.001) with ScvO2 levels and the concordance coefficient of 0.80 is high. The results suggest the potential of noninvasive SR-NIRS for bedside shock monitoring.

Keywords: (170.1470) Blood or tissue constituent monitoring; (300.0300) Spectroscopy.

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Figures

**Fig. 1**
Portable spatially-resolved near-infrared spectroscopy (SR-NIRS) device for bedside shock monitoring. (a) SR-NIRS probe placement; (b) SR-NIRS shock monitor device; (c) Bedside shock monitoring.

**Fig. 2**
(a) Ultrasonograph of internal jugular central vein and (b) Monte Carlo simulation of photon paths within the tissues surrounding the veins.

**Fig. 3**
The correlations between StO₂ and conventional blood oxygen indices, represented by scatter plot with least-squares fitted lines added.

**Fig. 4**
NIRS-measured StO₂ compared to the gold standard ScvO₂ from the blood sample test. (a) The solid line represents the best fit to the data; the dashed line indicates the perfect equivalent; and the dot line denotes the 95% confidence interval for StO₂. (b) Bland-Altman plot of the deference between the StO₂ and ScvO₂ as well as the mean difference (solid horizontal line) between these two parameters. The dash lines indicate the 95% limits of an agreement.

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Bedside monitoring of patients with shock using a portable spatially-resolved near-infrared spectroscopy

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Bedside monitoring of patients with shock using a portable spatially-resolved near-infrared spectroscopy

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