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Comment
. 2015 Oct;47(10):1104-5.
doi: 10.1038/ng.3407.

Adeno-associated virus finds its disease

David W Russell  1 , Markus Grompe  2
Affiliations
Comment

Adeno-associated virus finds its disease

David W Russell et al. Nat Genet. 2015 Oct.

Abstract

Adeno-associated virus (AAV) vectors have been widely adopted for use in gene therapy. A new study raises concerns regarding this approach, reporting that chromosomal insertions of AAV serotype 2 seem to activate proto-oncogenes in human hepatocellular carcinoma.

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Conflict of interest statement

COMPETING FINANCIAL INTERESTS

The authors declare competing financial interests: details are available in the online version of the paper.

Figures

Figure 1
Figure 1
AAV and hepatocellular carcinoma. Genomic integration of wild-type (WT) or engineered AAV sequences in human or mouse hepatocytes can lead to HCC through activation of proto-oncogene expression. Pro/enh, promoter-enhancer.
See this image and copyright information in PMC

Comment on

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