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Comment
. 2015 Oct;47(10):1105-6.
doi: 10.1038/ng.3411.

PRC1 proteins orchestrate three-dimensional genome architecture

Giacomo Cavalli  1
Affiliations
Comment

PRC1 proteins orchestrate three-dimensional genome architecture

Giacomo Cavalli. Nat Genet. 2015 Oct.

Abstract

The three-dimensional organization of the genome has an important role in orchestrating gene expression, but its regulation is poorly understood. Now, a new study uncovers a major role for Polycomb components of the PRC1 complex in organizing physical networks of genes that are co-repressed to maintain pluripotency.

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  • Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome.
    Schoenfelder S, Sugar R, Dimond A, Javierre BM, Armstrong H, Mifsud B, Dimitrova E, Matheson L, Tavares-Cadete F, Furlan-Magaril M, Segonds-Pichon A, Jurkowski W, Wingett SW, Tabbada K, Andrews S, Herman B, LeProust E, Osborne CS, Koseki H, Fraser P, Luscombe NM, Elderkin S. Schoenfelder S, et al. Nat Genet. 2015 Oct;47(10):1179-1186. doi: 10.1038/ng.3393. Epub 2015 Aug 31. Nat Genet. 2015. PMID: 26323060 Free PMC article.

References

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