What if stem cells turn into embryos in a dish?

Martin F Pera^{1

2

3}, Guido de Wert⁴, Wybo Dondorp⁴, Robin Lovell-Badge⁵, Christine L Mummery⁶, Megan Munsie¹, Patrick P Tam^{7

8}

Affiliations

¹ Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, Australia.
² The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia.
³ The Florey Neuroscience and Mental Health Institute, Parkville, Victoria, Australia.
⁴ Department of Health, Ethics &Society, Research Schools Care and Public Health Research Institute and GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
⁵ Francis Crick Institute, Mill Hill, London, UK.
⁶ Department of Anatomy and Embryology, Leiden University Medical Centre, Leiden, The Netherlands.
⁷ Embryology Unit, Children's Medical Research Institute, Westmead, New South Wales, Australia.
⁸ Discipline of Medicine, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

PMID: 26418764
DOI: 10.1038/nmeth.3586

What if stem cells turn into embryos in a dish?

Martin F Pera et al. Nat Methods. 2015 Oct.

. 2015 Oct;12(10):917-9.

doi: 10.1038/nmeth.3586.

Authors

Martin F Pera^{1

2

3}, Guido de Wert⁴, Wybo Dondorp⁴, Robin Lovell-Badge⁵, Christine L Mummery⁶, Megan Munsie¹, Patrick P Tam^{7

8}

Affiliations

¹ Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, Australia.
² The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia.
³ The Florey Neuroscience and Mental Health Institute, Parkville, Victoria, Australia.
⁴ Department of Health, Ethics &Society, Research Schools Care and Public Health Research Institute and GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
⁵ Francis Crick Institute, Mill Hill, London, UK.
⁶ Department of Anatomy and Embryology, Leiden University Medical Centre, Leiden, The Netherlands.
⁷ Embryology Unit, Children's Medical Research Institute, Westmead, New South Wales, Australia.
⁸ Discipline of Medicine, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

PMID: 26418764
DOI: 10.1038/nmeth.3586

Abstract

Recent studies show that pluripotent stem cells can undergo self-organized development in vitro into structures that mimic the body plan of the post-implantation embryo. Modeling human embryogenesis in a dish opens up new possibilities for the study of early development and developmental disorders, but it may also raise substantial ethical concerns.

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References

1. Sci Rep. 2015 May 12;5:10038 - PubMed
1. Nat Rev Genet. 2007 May;8(5):368-81 - PubMed
1. Stem Cell Reports. 2014 May 22;2(6):881-95 - PubMed
1. Development. 2014 Nov;141(22):4231-42 - PubMed
1. Cell. 2015 Jan 15;160(1-2):253-68 - PubMed

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What if stem cells turn into embryos in a dish?

Affiliations

What if stem cells turn into embryos in a dish?

Authors

Affiliations

Abstract

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources