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Review
. 2016 Jan;19(1):31-6.
doi: 10.1097/MCO.0000000000000230.

Osteoporosis and sarcopenia: two diseases or one?

Jean-Yves Reginster  1 , Charlotte Beaudart, Fanny Buckinx, Olivier Bruyère
Affiliations
Review

Osteoporosis and sarcopenia: two diseases or one?

Jean-Yves Reginster et al. Curr Opin Clin Nutr Metab Care. 2016 Jan.

Abstract

Purpose of review: This article reviews recently published evidence for common pathways explaining bone and muscle wasting in normal ageing and pathological conditions.

Recent findings: Numerous studies support the concept of a bone-muscle unit, where constant cross-talking between the two tissues takes place, involving molecules released by the skeletal muscle secretome, which affects bone, and osteokines secreted by the osteoblasts and osteocytes, which, in turn, impact muscle cells.

Summary: New chemical entities aiming at concomitantly treating osteoporosis and sarcopenia could be developed by targeting pathways that centrally regulate bone and muscle or emerging pathways that facilitate the communication between the two tissues.

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References

    1. Curtis E, Litwic A, Cooper C, Dennison E. Determinants of muscle and bone aging. J Cell Physiol 2015; 230:2618–2625. - PMC - PubMed
    1. Kanis JA, McCloskey EV, Johansson H, et al. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 2013; 24:23–57. - PMC - PubMed
    1. Dupuy C, Lauwers-Cances V, Guyonnet S, et al. Searching for a relevant definition of sarcopenia: results from the cross-sectional EPIDOS study. J Cachexia Sarcopenia Muscle 2015; 6:144–154. - PMC - PubMed
    1. Beaudart C, Reginster JY, Slomian J, et al. Estimation of sarcopenia prevalence using various assessment tools. Exp Gerontol 2015; 61:31–37. - PubMed
    1. Beaudart C, Rizzoli R, Bruyere O, et al. Sarcopenia: burden and challenges for public health. Arch Public Health 2014; 72:45. - PMC - PubMed