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Case Reports
. 2015 Sep 29:8:496.
doi: 10.1186/s13104-015-1522-0.

Individual time course of pre- and postsynaptic PET imaging may improve differential diagnosis of Parkinson's disease and multiple system atrophy: a case report

Kenji Ishibashi  1 , Hirofumi Nishina  2 , Kiichi Ishiwata  3 , Kenji Ishii  4
Affiliations
Case Reports

Individual time course of pre- and postsynaptic PET imaging may improve differential diagnosis of Parkinson's disease and multiple system atrophy: a case report

Kenji Ishibashi et al. BMC Res Notes. .

Abstract

Background: Many in vivo studies have shown a difference in pre- and/or postsynaptic imaging between Parkinson's disease and multiple system atrophy; however, time course differences in pre- and postsynaptic imaging between Parkinson's disease and multiple system atrophy have not been rigorously investigated.

Case presentation: We report serial positron emission tomography images of both dopamine transporters and dopamine D2 receptors, obtained from a Japanese patient with Parkinson's disease who underwent positron emission tomography scanning at ages 71, 72, 74, and 75 years, and another Japanese patient with multiple system atrophy who underwent positron emission tomography scanning at ages 65, 66, and 67 years. Volumes-of-interest were placed on the striatal subregions. The percentage decreases between the first and last images showed that dopamine transporter availability decreased with disease progression in both patients, but that dopamine D2 receptor availability decreased only in the patient with multiple system atrophy. A partial correlation analysis between dopamine transporter and dopamine D2 receptor availability, controlling for the effects of striatal subregional differences, revealed a positive correlation in the patient with multiple system atrophy (r = 0.893, P = 0.0002), but no significant correlation in the patient with Parkinson's disease (r = -0.036, P = 0.89).

Conclusions: The time course of pre- and postsynaptic imaging can be considerably different between Parkinson's disease and multiple system atrophy, and may be useful in improving the accuracy of discrimination between Parkinson's disease and multiple system atrophy.

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Figures

Fig. 1
Fig. 1
Comparison of the time course of dopamine transporter and dopamine D2 receptor availability between the patient with Parkinson’s disease and the patient with multiple system atrophy. Data in all striatal subregions from the first to last images were used. The horizontal and vertical axes represent the Z scores of dopamine transporter and dopamine D2 receptor availability, respectively. Black, blue, red, yellow, and green circles represent data from the ventral striatum, pre-commissural dorsal caudate, post-commissural caudate, pre-commissural dorsal putamen, and post-commissural putamen, respectively. Open and closed circles represent the patient with Parkinson’s disease and multiple system atrophy, respectively. The partial correlation, controlling for the effects of regional differences, is significant in the patient with multiple system atrophy (r = 0.893, P = 0.0002), but not in the patient with Parkinson’s disease (r = −0.036, P = 0.89)
Fig. 2
Fig. 2
Dopamine transporter and dopamine D2 receptor images. The first and last images of dopamine transporters and dopamine D2 receptors in the patient with Parkinson’s disease and the patient with multiple system atrophy are displayed in axial sections. The rainbow scale represents the magnitude of uptake ratio index
See this image and copyright information in PMC

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