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Review
. 2016 Feb;17(1):3-14.
doi: 10.1111/pedi.12323. Epub 2015 Sep 30.

Metabolomics in childhood diabetes

Brigitte I Frohnert  1 , Marian J Rewers  1
Affiliations
Review

Metabolomics in childhood diabetes

Brigitte I Frohnert et al. Pediatr Diabetes. 2016 Feb.

Abstract

Recent increases in the incidence of both type 1 (T1D) and type 2 diabetes (T2D) in children and adolescents point to the importance of environmental factors in the development of these diseases. Metabolomic analysis explores the integrated response of the organism to environmental changes. Metabolic profiling can identify biomarkers that are predictive of disease incidence and development, potentially providing insight into disease pathogenesis. This review provides an overview of the role of metabolomic analysis in diabetes research and summarizes recent research relating to the development of T1D and T2D in children.

Keywords: autoimmunity; diabetes; lipidomics; metabolomics.

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Figures

Fig. 1
Fig. 1
Scheme for Design and Process of Metabolomic Study. NMR: nuclear magnetic resonance spectroscopy; MS: mass spectrometry (10, 89).
See this image and copyright information in PMC

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