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. 2015 Oct 26;21(44):15525-8.
doi: 10.1002/chem.201503624. Epub 2015 Sep 30.

Cobalt(III)-Catalyzed C-H/N-O Functionalizations: Isohypsic Access to Isoquinolines

Hui Wang  1 , Julian Koeller  1 , Weiping Liu  1 , Lutz Ackermann  2
Affiliations

Cobalt(III)-Catalyzed C-H/N-O Functionalizations: Isohypsic Access to Isoquinolines

Hui Wang et al. Chemistry. .

Abstract

C-H/N-O functionalizations by cobalt(III) catalysis allowed the expedient synthesis of a broad range of isoquinolines. Thus, internal and challenging terminal alkynes proved to be viable substrates for an isohypsic annulation, which was shown to proceed by a facile C-H cobaltation.

Keywords: CH activation; N-O cleavage; alkyne; cobalt; isoquinoline.

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