Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2016 Apr;24(4):1697-707.
doi: 10.1007/s00520-015-2955-7. Epub 2015 Sep 30.

A randomised controlled trial comparing the effects of a 12-week supervised exercise versus usual care on outcomes in haematological cancer patients

Bonnie J Furzer  1   2 , Timothy R Ackland  3 , Karen E Wallman  3 , Anna S Petterson  4   5 , Sandy M Gordon  3 , Kemi E Wright  3 , David J L Joske  3   4   6
Affiliations
Randomized Controlled Trial

A randomised controlled trial comparing the effects of a 12-week supervised exercise versus usual care on outcomes in haematological cancer patients

Bonnie J Furzer et al. Support Care Cancer. 2016 Apr.

Abstract

Purpose: Following treatment, haematological cancer (HEM) patients exhibit significant physical deconditioning and psychological distress. Exercise has been shown as a clinically effective and safe intervention for cancer patients, with the potential to reverse the deleterious effects following treatment. Our aim was to investigate the efficacy of a 12-week exercise rehabilitation on cancer-related fatigue (CRF) and associated outcomes in HEM patients post-treatment.

Methods: Patients with a HEM were recruited to participate in a 12-week exercise rehabilitation intervention post-treatment. Pre-, post- and follow-up assessments were conducted on outcome measures including CRF, quality of life (QoL), psychological distress, cardiovascular fitness, muscle strength (MS) and body composition. Patients were given tailored exercise programmes comprising aerobic and resistance exercises, carried out three times per week for 12 weeks in local gyms and clinics. Usual-care participants were offered a delayed, tailored 12-week exercise intervention after the initial study period.

Results: Thirty-seven patients (49 % recruitment rate) were randomly assigned to the 12-week exercise rehabilitation (n = 18) or usual care (n = 19) with a 91 % adherence to the exercise intervention. Following the exercise programme, significant improvements were seen in CRF (p = 0.01), cardiovascular fitness (p ≤ 0.001), QoL (p ≤ 0.001), MS (p ≤ 0.001) and body composition (p = 0.001), with moderate to large effects for all primary outcomes. Patient follow-up at 24 weeks demonstrated outcome maintenance in the exercise rehabilitation group and significant improvements in outcomes in usual-care patients following participation in a delayed exercise programme. There were no adverse reactions or study withdrawals.

Conclusions: A 12-week exercise rehabilitation programme resulted in significant statistical (p ≤ 0.05) and clinical improvements in CRF and additional outcomes in HEM patients following treatment. Additionally, a 12-week delayed exercise programme showed similar significant improvements in patient outcomes.

Trial registration: Australian New Zealand Clinical Trials Registry ACTRN12609000450213.

Keywords: Exercise; Fatigue; Haematological cancer; Physical function; Quality of life; Supportive care.

PubMed Disclaimer

References

    1. Psychooncology. 2012 Oct;21(10):1124-31 - PubMed
    1. Cancer Treat Rev. 2009 Apr;35(2):185-92 - PubMed
    1. Sports Med. 2012 Mar 1;42(3):227-49 - PubMed
    1. Mayo Clin Proc. 2014 Oct;89(10):1465 - PubMed
    1. Med Sci Sports Exerc. 1982;14(5):377-81 - PubMed

Publication types