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Review
. 2015 Dec;89(24):12242-4.
doi: 10.1128/JVI.01452-15. Epub 2015 Sep 30.

Intercellular Transmission of Viral Populations with Vesicles

Nihal Altan-Bonnet  1 , Ying-Han Chen  2
Affiliations
Review

Intercellular Transmission of Viral Populations with Vesicles

Nihal Altan-Bonnet et al. J Virol. 2015 Dec.

Abstract

A common paradigm holds that during cell-to-cell transmission, viruses behave as lone soldiers. Recently, we discovered not only that enteroviruses are transmitted via vesicles as populations of viral particles but also that this type of transmission enhances their infection efficiency (Y. H. Chen et al., Cell 160: 619-630, 2015). This mechanism could be advantageous for the overall fitness of the viral population, promoting genetic interplay by enabling viral quasispecies to collectively infect a susceptible host cell. Here, we discuss these findings in the context of viral pathogenesis and also propose that this novel type of vesicular transmission is widespread among different virus families and includes populations of both viral particles and naked viral genomes.

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Figures

FIG 1
FIG 1
(A) Single viral RNA molecules detected by FISH, prior to replication, in a cell infected with free poliovirus particles. (B) Cartoon diagram of spatially segregated replication organelles in a cell infected with free viral particles. (C) Single viral RNA molecules detected by FISH, prior to replication, in a cell infected with vesicles containing a population of poliovirus particles. (D) Cartoon diagram of spatially clustered replication organelles in a cell infected with a vesicle containing a population of poliovirus particles.
See this image and copyright information in PMC

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