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. 2015 Oct 1;21(4):528-36.
doi: 10.5056/jnm15074.

Association of the Extent of Atrophic Gastritis With Specific Dyspeptic Symptoms

Sook Hee Chung  1 , Kwang Jae Lee  1 , Ja Yeon Kim  2 , Seon Gyo Im  1 , Eunkyung Kim  1 , Min Jae Yang  1 , Seo Hee Ryu  1
Affiliations

Association of the Extent of Atrophic Gastritis With Specific Dyspeptic Symptoms

Sook Hee Chung et al. J Neurogastroenterol Motil. .

Abstract

Background/aims: It remains unclear whether atrophic gastritis can affect dyspeptic symptoms. We aimed to investigate whether the extent of atrophic gastritis is associated with specific dyspeptic symptoms.

Methods: Consecutive adults in a routine health-checkup program were enrolled in the study. The extent of atrophic gastritis was classified into 3 groups based on the Kimura-Takemoto criteria; the gastritis with no or little atrophy (group A: C0), the gastritis with atrophy mainly in the antrum (group B: C1 and C2), and the gastritis with atrophy in the large area of the corpus (group C: C3 and O). Upper gastrointestinal symptoms were categorized into "typical reflux symptoms," "epigastric pain syndrome (EPS)-related symptoms," and "postprandial distress syndrome (PDS)-related symptoms."

Results: A total of 1827 patients (1009 males, mean age 45.1 years) were included in the analysis. The subgroups of atrophic gastritis were as follows: group A (n = 1218, 66.7%), group B (n = 392, 21.4%), and group C (n = 217, 11.9%). Typical reflux, EPS-related, and PDS-related symptoms were present in 10.5%, 19.8%, and 16.2% of the subjects, respectively. PDS-related and EPS-related symptoms were significantly more prevalent in the group C of male patients and the group B of female patients, respectively, compared with other groups. PDS-related and EPS-related symptoms were independently associated with the group C in males (OR, 2.123; 95% CI, 1.090-4.136) and the group B in females (OR, 2.571; 95% CI, 1.319-5.025), respectively.

Conclusions: The extent of atrophic gastritis appears to affect the generation of specific dyspeptic symptoms in a gender-dependent manner.

Keywords: Atrophic gastritis; Dyspepsia; Epigastric pain syndrome; Postprandial distress syndrome.

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Figures

Figure 1.
Figure 1.
Inclusion and exclusion flow chart for enrollment of study participants. The extent of atrophic gastritis was classified as C0, C1, C2, C3, and O, based on the endoscopic classification system suggested by Kimura et al, and Suzuki and Moayyedi. EGD, esophagogastroduodenoscopy; GI, gastrointestinal.
Figure 2.
Figure 2.
The classification of atrophic patterns in the stomach suggested by Kimura et al, and Suzuki and Moayyedi. This classification divides the extent of atrophy into a closed type (C-type) and an open type (O-type).
Figure 3.
Figure 3.
Endoscopic findings indicating the absence of atrophy in the antrum (A1) and corpus (A2), and the presence of atrophy in the antrum (B1) and corpus (B2).
See this image and copyright information in PMC

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