Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Jan;57(1):291-4.
doi: 10.1128/iai.57.1.291-294.1989.

Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production

D J Fast  1 , P M Schlievert, R D Nelson
Affiliations

Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production

D J Fast et al. Infect Immun. 1989 Jan.

Abstract

Toxic shock syndrome-associated staphylococcal and streptococcal exotoxins were tested for an ability to induce the production of tumor necrosis factor (TNF). Staphylococcal enterotoxins B and C1, along with streptococcal pyrogenic exotoxin A, all induced TNF production in a dose-dependent manner, with production peaking on the average at 3 days but continuing over the 6 days tested. This time course of exotoxin-induced TNF production contrasts with the 1-day peak-2-day duration observed with endotoxin as the stimulus and may be significant to development of toxic shock syndrome.

PubMed Disclaimer

References

    1. JAMA. 1985 May 3;253(17):2538-42 - PubMed
    1. J Immunol Methods. 1983 Dec 16;65(1-2):55-63 - PubMed
    1. Cancer Res. 1985 Nov;45(11 Pt 1):5225-9 - PubMed
    1. J Leukoc Biol. 1985 Dec;38(6):735-46 - PubMed
    1. J Infect Dis. 1986 May;153(5):918-26 - PubMed

Publication types

LinkOut - more resources