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. 2015 Dec;4(2):191-6.
doi: 10.1007/s40119-015-0051-1. Epub 2015 Sep 30.

The Impact of Fractional Flow Reserve on Revascularization

Islam Y Elgendy  1 , Calvin Choi  1   2 , Anthony A Bavry  3   4
Affiliations

The Impact of Fractional Flow Reserve on Revascularization

Islam Y Elgendy et al. Cardiol Ther. 2015 Dec.

Abstract

Introduction: Fractional flow reserve (FFR) is recommended by society guidelines for assessment of the hemodynamic significance of intermediate coronary lesions when non-invasive evidence of myocardial ischemia is unavailable. However, the prevalence of FFR usage in current practice and how FFR values impact revascularization decisions are not well known.

Methods: At a single-center Veterans Administration Hospital, all subjects referred for coronary angiography for any indication from the period from May 2012 until January 2014 were prospectively entered into a database. FFR was measured in all intermediate coronary lesions (30-70% stenosis). Based on the FFR results, the lesions were categorized into 3 different groups: FFR > 0.80 (non-ischemic), FFR 0.75-0.80 (gray zone), and FFR < 0.75 (ischemic).

Results: A total of 1482 cardiac catheterizations were performed during the study period. FFR was performed in 347 (23%) of these procedures. The total numbers of intermediate coronary lesions evaluated with FFR were 429. The mean FFR value was 0.79 (median = 0.80; interquartile range 0.64-0.96). Among 211 non-ischemic lesions, revascularization was deferred in 201 (95%). In the gray-zone group (73 lesions), 35 (48%) lesions were treated with percutaneous coronary intervention (PCI), 11 (15%) lesions were referred for coronary artery bypass grafting surgery (CABG), and 27 (37%) lesions were treated medically. In the ischemic group (145 lesions), 82 (57%) lesions were treated with PCI, 41 (28%) lesions were referred for CABG, and 22 (15%) lesions were treated medically.

Conclusion: At a Veterans Administration Hospital, FFR was performed in approximately one out of four total catheterizations. FFR documented lack of ischemia in about half of the intermediate coronary lesions, and thus reduced the need for many revascularization procedures.

Keywords: Coronary angiogram; Fractional flow reserve; Percutaneous coronary intervention; Revascularization.

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Figures

Fig. 1
Fig. 1
Summary for the percentage of lesions in each group. a Percentage of lesions in each fractional flow reserve category. Distribution of treatment (medical, revascularization, or referral for CABG) in the non-ischemic group (b), gray-zone group (c), and ischemic group (d). CABG coronary artery bypass grafting surgery, PCI percutaneous coronary intervention
See this image and copyright information in PMC

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