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Review
. 1989 Jan;32(1):64-7.
doi: 10.1021/jm00121a013.

Amine peroxides as potential antimalarials

J L Vennerstrom  1
Affiliations
Review

Amine peroxides as potential antimalarials

J L Vennerstrom. J Med Chem. 1989 Jan.

Abstract

Six model amine peroxides (4-9) were synthesized as targeted antimalarial oxidants. They were approximately 1 order of magnitude more potent than tert-butyl hydroperoxide (3) in vitro against Plasmodium falciparum, but like 3, they were inactive in vivo against Plasmodium berghei.

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