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. 2015 Aug 21;2(8):667-8.
doi: 10.18632/oncoscience.210. eCollection 2015.

Immunosuppression via Tenascin-C

Matteo Bellone  1 , Sara Caputo  1 , Elena Jachetti  1
Affiliations

Immunosuppression via Tenascin-C

Matteo Bellone et al. Oncoscience. .
No abstract available

Keywords: cancer stem cell; immunosuppression; metastasis; prostate cancer; tenascin-c.

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Conflict of interest statement

CONFLICT OF INTEREST

No potential conflicts of interest were disclosed.

Figures

Figure 1
Figure 1. Prostate cancer stem-like cells early migrate to prostate draining lymph nodes through the CXCR4-CXCL12 axis, and dampen T cell responses with Tenascin-C
Already at the stage of PIN, prostate CSC are attracted to PLN by a CXCL12 gradient. Both at the primary site and in the metastatic niche CSC use TNC to overcome immune surveillance. Drugs that either block the CXCR4-CXCL12 or the TNC-α5β1 axes could reduce metastasis occurrence.
See this image and copyright information in PMC

Comment on

  • Oncoscience. 75:2095.

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