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. 2015 Nov 7;7(41):17249-53.
doi: 10.1039/c5nr05459a.

Micro-optical coherence tomography tracking of magnetic gene transfection via Au-Fe3O4 dumbbell nanoparticles

Wei Shi  1 , Xinyu Liu, Chao Wei, Zhichuan J Xu, Stanley Siong Wei Sim, Linbo Liu, Chenjie Xu
Affiliations

Micro-optical coherence tomography tracking of magnetic gene transfection via Au-Fe3O4 dumbbell nanoparticles

Wei Shi et al. Nanoscale. .

Abstract

Heterogeneous Au-Fe3O4 dumbbell nanoparticles (NPs) are composed of Au NPs and Fe3O4 NPs that bring in optical and magnetic properties respectively. This article reports the engineering of Au-Fe3O4 NPs as gene carriers for magnetic gene transfection as well as contrast agents for micro-optical coherence tomography (μOCT). As a proof-of-concept, Au-Fe3O4 NPs are used to deliver the green fluorescent protein to HEK 293T cells and their entrance into the cells is monitored through μOCT.

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