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Observational Study
. 2016;32(1):78-81.
doi: 10.3109/09513590.2015.1092133. Epub 2015 Oct 1.

Adipokinins in pregnancies at risk of preterm delivery

Michelle A Kominiarek  1 , Cecilia T Gambala  2 , Monique Sutherland  1 , Krista Varady  3
Affiliations
Observational Study

Adipokinins in pregnancies at risk of preterm delivery

Michelle A Kominiarek et al. Gynecol Endocrinol. 2016.

Abstract

Objective: To compare adipokinins between women experiencing preterm labor (PTL) and prior preterm deliveries (PTD).

Study design: In this prospective observational cohort, 110 women with a singleton <35 weeks at increased risk of PTD were studied. Serum leptin, adiponectin, and resistin were obtained at three times (23-34 weeks, 35-36 weeks, at delivery) and analyzed via enzyme-linked immunosorbent assay. The adipokinins were compared across time and between PTL (n = 59) and prior PTD (n = 51) groups using generalized estimated equation models.

Results: There were no differences in leptin, adiponectin, or resistin levels over the three times between the PTL and PTD groups. There was a trend toward higher leptin levels (p = 0.06 unadjusted analysis, p = 0.09 adjusted analysis) at 23-34 weeks. When stratified by body mass index (BMI), there were differences in leptin (p < 0.001 for BMI < 30; p = 0.77 for BMI ≥ 30) and adiponectin (p = 0.04 for BMI < 30; p = 0.09 for BMI ≥ 30), but not in resistin over the three times between the PTL and prior PTD groups.

Conclusion: There were no significant differences in adipokinins in women with PTL and a prior PTD. The trends toward higher leptin levels at 23-34 weeks in women with PTL may represent a compensatory response and require further evaluation in the study of treatments for PTL.

Keywords: Adipokinins; obesity; pregnancy; preterm delivery.

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Conflict of interest statement

Declarations of Interest

Dr. Kominiarek has a K23 Mentored Career Development Award from the NIH/NICHD. Dr. Varady has R01 funding from the NIH/NHLBI. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health Drs. Gambala and Sutherland have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Comparison of Adipokinin Levels (ng/mL) in Preterm Labor (PTL) vs. Prior Preterm Delivery (PTD) Groups across Time. Analysis adjusted for prepregnancy body mass index, nulliparity, prior preterm delivery, progesterone use, and corticosteroids for fetal lung maturity.
Figure 2
Figure 2
Leptin and Adiponectin Levels (ng/mL) in Preterm Labor (PTL) vs. Prior Preterm Delivery (PTD) by Body Mass Index (BMI) across Time.
See this image and copyright information in PMC

References

    1. Hamilton BE, Martin JA, Ventura SJ. Births: preliminary data for 2012. National vital statistics reports: from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System. 2013;62(3):1–20. - PubMed
    1. Meis PJ, Michielutte R, Peters TJ, Wells HB, Sands RE, Coles EC, et al. Factors associated with preterm birth in Cardiff, Wales. I. Univariable and multivariable analysis. Am J Obstet Gynecol. 1995;173(2):590–6. - PubMed
    1. Harlow BL, Frigoletto FD, Cramer DW, Evans JK, LeFevre ML, Bain RP, et al. Determinants of preterm delivery in low-risk pregnancies. The RADIUS Study Group. J Clin Epidemiol. 1996;49(4):441–8. - PubMed
    1. Kyrklund-Blomberg NB, Cnattingius S. Preterm birth and maternal smoking: risks related to gestational age and onset of delivery. Am J Obstet Gynecol. 1998;179(4):1051–5. - PubMed
    1. Nicholson W, Croughan-Minihane M, Posner S, Washington AE, Kilpatrick SK. Preterm delivery in patients admitted with preterm labor: a prediction study. J Matern Fetal Med. 2001;10(2):102–6. - PubMed

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