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Review
. 2015 Oct;59(4):761-80.
doi: 10.1016/j.cden.2015.06.005. Epub 2015 Aug 1.

What is the Contribution of Genetics to Periodontal Risk?

Bruno G Loos  1 , Georgios Papantonopoulos  2 , Søren Jepsen  3 , Marja L Laine  4
Affiliations
Review

What is the Contribution of Genetics to Periodontal Risk?

Bruno G Loos et al. Dent Clin North Am. 2015 Oct.

Abstract

This review addresses the multicausal etiology of periodontitis, in which genetic factors play a role. The various proposed causes for periodontitis always work simultaneously, but the relative contribution of each of these varies from case to case. We are still at an early stage to identify the genes involved, in comparison with other chronic diseases. To date, the genetic variations firmly and repeatedly associated with periodontitis in some populations are found within the following genes: ANRIL, COX2, IL1, IL10, DEFB1, whereas many other proposed periodontitis candidate genes have not been firmly proven or replicated.

Keywords: Candidate gene; Complex disease; Etiology; GWAS; Genetics; Multi-causality; Periodontitis.

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