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. 2015 Oct 2:19:356.
doi: 10.1186/s13054-015-1062-y.

Six-month quality-of-life and functional status of acute respiratory distress syndrome survivors compared to patients at risk: a population-based study

Michelle Biehl  1   2   3 , Rahul Kashyap  4 , Adil H Ahmed  5   6 , Martin K Reriani  7   8 , Uchenna R Ofoma  9   10 , Gregory A Wilson  11 , Guangxi Li  12   13 , Michael Malinchoc  14   15 , Jeff A Sloan  16 , Ognjen Gajic  17   18
Affiliations

Six-month quality-of-life and functional status of acute respiratory distress syndrome survivors compared to patients at risk: a population-based study

Michelle Biehl et al. Crit Care. .

Abstract

Introduction: The long-term attributable burden related to acute respiratory distress syndrome (ARDS) is not fully investigated. The aim of this study is to evaluate the quality of life (QOL) and functional status at 6 months after hospitalization in patients at risk for ARDS who did and did not develop the syndrome.

Method: This is a population-based prospective cohort study of adult patients from Olmsted County, Minnesota, with or at risk for ARDS hospitalized from October 2008 to July 2011. The primary outcomes were changes in QOL and functional status, measured through 12-Item Short Form Survey (SF-12) and Barthel Index (BI) respectively, from baseline to 6 months, compared between survivors who did and did not develop ARDS.

Results: Of 410 patients with or at risk for ARDS, 98 had baseline surveys collected and 67 responded to a 6-month survey (26 ARDS, 41 non-ARDS). Both ARDS and non-ARDS groups had lower physical component of SF-12 at baseline compared to general population (P < 0.001 for both). ARDS patients had poorer baseline functional status compared to non-ARDS (mean BI 80 ± 25 vs. 88 ± 22, P = 0.03). No significant differences were observed for the change between 6 months and baseline BI (delta 2.3 for ARDS vs. 2.0 for non-ARDS, P = 0.5), or mental (delta 2.7 vs. 2.4, P = 0.9) or physical (delta -3 vs. -3.3, P = 0.9) component of SF-12 between survivors with and without ARDS.

Conclusion: In this population-based study, decreased QOL and functional status 6 months after hospitalization were largely explained by baseline condition, with similar recovery in survivors who did and did not develop ARDS.

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Figures

Fig. 1
Fig. 1
Consolidated Standards of Reporting Trials (CONSORT) flowchart diagram. ARDS acute respiratory distress syndrome
Fig. 2
Fig. 2
Mental and physical component scores for the 12-item Short Form Survey (SF-12) measured at baseline and 6 months in patients with acute respiratory distress syndrome (ARDS) and patients without ARDS (non-ARDS). MCS mental component score, PCS physical component score
See this image and copyright information in PMC

References

    1. Avecillas JF, Freire AX, Arroliga AC. Clinical epidemiology of acute lung injury and acute respiratory distress syndrome: incidence, diagnosis, and outcomes. Clinics in chest medicine. 2006;27(4):549–557. doi: 10.1016/j.ccm.2006.06.001. - DOI - PubMed
    1. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000;342(18):1301-1308. - PubMed
    1. Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D. deBoisblanc B et al. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006;354(24):2564–2575. doi: 10.1056/NEJMoa062200. - DOI - PubMed
    1. Herridge MS, Cheung AM, Tansey CM, Matte-Martyn A, Diaz-Granados N, Al-Saidi F, et al. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med. 2003;348(8):683–693. doi: 10.1056/NEJMoa022450. - DOI - PubMed
    1. Cheung AM, Tansey CM, Tomlinson G, Diaz-Granados N, Matte A, Barr A, et al. Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med. 2006;174(5):538–544. doi: 10.1164/rccm.200505-693OC. - DOI - PubMed

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