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. 2016 Jan;84(1):52-54.
doi: 10.1016/j.diagmicrobio.2015.08.012. Epub 2015 Aug 28.

Candida lusitaniae MICs to the echinocandins are elevated but FKS-mediated resistance is rare

Shawn R Lockhart  1 , Cau D Pham  2 , Randall J Kuykendall  2 , Carol B Bolden  2 , Angela A Cleveland  2
Affiliations

Candida lusitaniae MICs to the echinocandins are elevated but FKS-mediated resistance is rare

Shawn R Lockhart et al. Diagn Microbiol Infect Dis. 2016 Jan.

Abstract

MIC values were generated for caspofungin, micafungin, and anidulafungin against 106 isolates of C. lusitaniae, and these values were compared to established epidemiologic cutoff values. The majority of isolates were wild type both by MIC value as well as by FKS1 hotspot sequencing. Although C. lusitaniae isolates have MIC values to the echinocandins that are elevated compared to other common species, with regard to known mechanisms of resistance to the echinocandins, isolates with MIC values at or below the epidemiological cutoff values of 0.5 and 1 μg/mL for micafungin and anidulafungin, respectively, should be considered wild type.

Keywords: Candida lusitaniae; Echinocandin; Epidemiological cutoff value; FKS.

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References

    1. Wisplinghoff H, Ebbers J, Geurtz L, Stefanik D, Major Y, Edmond MB, Wenzel RP, Seifert H. Nosocomial bloodstream infections due to Candida spp. in the USA: species distribution, clinical features and antifungal susceptibilities. International J. Antimicrob. Agents. 2014;43:78–81. - PubMed
    1. Hidron AI, Edwards JR, Patel J, Horan TC, Sievert DM, Pollock DA, Fridkin SK. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006–2007. Infect. Contrl. Hosp. Epidemiol. 2008;29:996–1011. - PubMed
    1. Pfaller MA, Messer SA, Moet GJ, Jones RN, Castanheira M. Candida bloodstream infections: comparison of species distribution and resistance to echinocandin and azole antifungal agents in Intensive Care Unit (ICU) and non-ICU settings in the SENTRY Antimicrobial Surveillance Program (2008–2009) Intnational. J antimicrobial agents. 2011;38:65–69. - PubMed
    1. Lyon GM, Karatela S, Sunay S, Adiri Y. Antifungal susceptibility testing of Candida isolates from the Candida surveillance study. Journal of clinical microbiology. 2010;48:1270–1275. - PMC - PubMed
    1. Lockhart SR, Iqbal N, Cleveland AA, Farley MM, Harrison LH, Bolden CB, Baughman W, Stein B, Hollick R, Park BJ, Chiller T. Species identification and antifungal susceptibility testing of Candida bloodstream isolates from population-based surveillance studies in two U.S. cities from 2008 to 2011. Journal of clinical microbiology. 2012;50:3435–3442. - PMC - PubMed

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