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Comment
. 2015 Oct 1;126(14):1637-8.
doi: 10.1182/blood-2015-08-662502.

MAGiC: VOC remains but kids with SCA appear

Jeremie Heath Estepp  1
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Free article
Comment

MAGiC: VOC remains but kids with SCA appear

Jeremie Heath Estepp. Blood. .
Free article

Abstract

In this issue of Blood, Brousseau et al report results from the Magnesium for Children in Crisis (MAGiC; #NCT01197417) trial. This multicenter, double-blind, placebo-controlled trial compared the effects of intravenous magnesium to saline in children with sickle cell anemia (SCA) admitted to the hospital for acute vaso-occlusive pain (VOC). Although magnesium was found to be ineffective, MAGiC illustrates an effective strategy for rapid and efficient patient accrual in pediatric SCA studies.

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  • A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children.
    Brousseau DC, Scott JP, Badaki-Makun O, Darbari DS, Chumpitazi CE, Airewele GE, Ellison AM, Smith-Whitley K, Mahajan P, Sarnaik SA, Casper TC, Cook LJ, Dean JM, Leonard J, Hulbert ML, Powell EC, Liem RI, Hickey R, Krishnamurti L, Hillery CA, Nimmer M, Panepinto JA; Pediatric Emergency Care Applied Research Network (PECARN). Brousseau DC, et al. Blood. 2015 Oct 1;126(14):1651-7. doi: 10.1182/blood-2015-05-647107. Epub 2015 Jul 31. Blood. 2015. PMID: 26232172 Free PMC article. Clinical Trial.

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