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Comment
. 2015 Oct 1;21(19):4248-50.
doi: 10.1158/1078-0432.CCR-15-1381.

CCR 20th Anniversary Commentary: Bevacizumab in the Treatment of Glioblastoma--The Progress and the Limitations

Nataliya Mar  1 , Annick Desjardins  2 , James J Vredenburgh  3
Affiliations
Comment

CCR 20th Anniversary Commentary: Bevacizumab in the Treatment of Glioblastoma--The Progress and the Limitations

Nataliya Mar et al. Clin Cancer Res. .

Abstract

Vredenburgh and colleagues conducted the first phase II study of bevacizumab plus irinotecan in recurrent malignant glioma, confirming the safety and efficacy of bevacizumab. This study, which was published in the February 15, 2007, issue of Clinical Cancer Research, was a stepping stone for subsequent research, leading to regulatory approval of bevacizumab for recurrent glioblastoma.

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Comment on

  • Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma.
    Vredenburgh JJ, Desjardins A, Herndon JE 2nd, Dowell JM, Reardon DA, Quinn JA, Rich JN, Sathornsumetee S, Gururangan S, Wagner M, Bigner DD, Friedman AH, Friedman HS. Vredenburgh JJ, et al. Clin Cancer Res. 2007 Feb 15;13(4):1253-9. doi: 10.1158/1078-0432.CCR-06-2309. Clin Cancer Res. 2007. PMID: 17317837 Clinical Trial.

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