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. 2016 Jan;62(1):297-9.
doi: 10.1373/clinchem.2015.245266. Epub 2015 Oct 1.

First Steps toward Harmonization of LC-MS/MS Thyroglobulin Assays

Brian C Netzel  1 , Russell P Grant  2 , Andrew N Hoofnagle  3 , Alan L Rockwood  4 , Christopher M Shuford  2 , Stefan K G Grebe  5
Affiliations

First Steps toward Harmonization of LC-MS/MS Thyroglobulin Assays

Brian C Netzel et al. Clin Chem. 2016 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Method comparison of all TgMS, and TgIA assays. Mean values of all TgMS and TgIA assays are on the abscissas and differentiated assay values are on the ordinate. In each case a single color represents a single assay, and a star represents a TgAb- specimen, where a solid circle represents a TgAb+ specimen. Linear regression is represented across all specimens (both TgAb- and TgAb+). For TgMS, slopes are: 1.102, 1.027, 1.043, and 0.833, while r2 are: 0.988, 0.996, 0.981, and 0.961 for Mayo, LabCorp, UWash, and ARUP, respectively. For TgIA, slopes are: 1.029, 0.876, 0.803 and 1.297 and r2 are: 0.983, 0.911, 0.971 and 0.993 for the DxI, Immulite, Kryptor and Elecsys TgIA, respectively. As a point of note, the bias induced by TgAb-positivity into the Tg measurements by the TgIAs is of a comparable magnitude in all but the Immulite assay. This explains why there is no apparent large bias between most of the TgIAs in measurements of TgAb positive samples. For further details on this subject we point the reader to the supplemental material published with reference number 2.
See this image and copyright information in PMC

References

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