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Published Erratum
. 2015 Oct 20;112(42):E5764.
doi: 10.1073/pnas.1518632112. Epub 2015 Oct 1.

Correction for Jiménez-Díaz et al., (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

No authors listed
Published Erratum

Correction for Jiménez-Díaz et al., (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

No authors listed. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 5.
Fig. 5.
Induction of eryptosis by SJ733 triggers rapid clearance in vivo. When (+)-SJ733 is added to erythrocytes infected with Plasmodium spp., it prevents the action of the putative Na+ ATPase PfATP4 and causes a significant increase in cytosolic Na+ within the parasite, reaching maximal effect within 90 min after treatment. This process results in the immediate arrest of parasite motility and blockade of intracellular parasite replication that reaches maximal potency after 24 h of exposure. Simultaneously, infected, treated erythrocytes begin to enter eryptosis, as characterized by their shrinking and becoming more spherical, becoming significantly more rigid, and exposing PS on their plasma membrane. These effects maximize by 7 h after treatment. In vitro, the drug effects lead to complete arrest of replication within 24 h of treatment, followed by slow death, which is maximal by 96 h. In stark contrast to the in vitro setting, the induction of eryptosis leads to rapid clearance of the infected, treated erythrocytes in vivo.
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Erratum for

  • (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.
    Jiménez-Díaz MB, Ebert D, Salinas Y, Pradhan A, Lehane AM, Myrand-Lapierre ME, O'Loughlin KG, Shackleford DM, Justino de Almeida M, Carrillo AK, Clark JA, Dennis AS, Diep J, Deng X, Duffy S, Endsley AN, Fedewa G, Guiguemde WA, Gómez MG, Holbrook G, Horst J, Kim CC, Liu J, Lee MC, Matheny A, Martínez MS, Miller G, Rodríguez-Alejandre A, Sanz L, Sigal M, Spillman NJ, Stein PD, Wang Z, Zhu F, Waterson D, Knapp S, Shelat A, Avery VM, Fidock DA, Gamo FJ, Charman SA, Mirsalis JC, Ma H, Ferrer S, Kirk K, Angulo-Barturen I, Kyle DE, DeRisi JL, Floyd DM, Guy RK. Jiménez-Díaz MB, et al. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5455-62. doi: 10.1073/pnas.1414221111. Epub 2014 Dec 1. Proc Natl Acad Sci U S A. 2014. PMID: 25453091 Free PMC article.

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