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Review
. 2015 Aug 24;7(8):e309.
doi: 10.7759/cureus.309.

Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review

Venkataramana Kandi  1 , Sabitha Vadakedath  2
Affiliations
Review

Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review

Venkataramana Kandi et al. Cureus. .

Abstract

DNA methylation, a process of adding a methyl group to DNA done by a DNA methyltransferase is a heritable (epigenetic) alteration leading to cancer, atherosclerosis, nervous disorders (Imprinting disorders), and cardiovascular diseases. The role of nutrition in DNA methylation is revealed by identification of methyl variable positions (MVP) on DNA. These regions are more susceptible to DNA methylations. Nutritional supplementation of folic acid and methionine in utero and in adults decreased epigenetic modifications due to its role in DNA metabolism (one carbon metabolism). Thus, in utero and adult supplementation of folic acid and methionine may reduce DNA methylation. This review attempts to highlight the process of DNA methylation, its effect on various diseases, and the probable protective role of nutrition.

Keywords: dna methylation; epigenetic modifications; imprinting disorders; methyltransferase.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Reactions contributing to DNA methylation
Figure 2
Figure 2. Flow chart showing various causes of hyper/hypo methylation of DNA leading to Atherosclerotic lesions
See this image and copyright information in PMC

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