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. 1989 Jan;86(1):302-6.
doi: 10.1073/pnas.86.1.302.

Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells

R G Goodwin  1 , S Lupton, A Schmierer, K J Hjerrild, R Jerzy, W Clevenger, S Gillis, D Cosman, A E Namen
Affiliations

Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells

R G Goodwin et al. Proc Natl Acad Sci U S A. 1989 Jan.

Abstract

A cDNA encoding biologically active human interleukin 7 was isolated by hybridization with the homologous murine clone. Nucleotide sequence analysis indicated that this cDNA was capable of encoding a protein of 177 amino acids with a signal sequence of 25 amino acids and a calculated mass of 17.4 kDa for the mature protein. Recombinant human interleukin 7 stimulated the proliferation of murine pre-B cells and was active on cells harvested from human bone marrow that are enriched for B-lineage progenitor cells. Analysis of RNA by blot hybridization demonstrated the presence of two size classes of interleukin 7 mRNA in human splenic and thymic tissue.

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