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Comparative Study
. 1989 Jan;86(2):458-61.
doi: 10.1073/pnas.86.2.458.

A highly potent insulin: des-(B26-B30)-[AspB10,TyrB25-NH2]insulin(human)

G P Schwartz  1 , G T Burke, P G Katsoyannis
Affiliations
Comparative Study

A highly potent insulin: des-(B26-B30)-[AspB10,TyrB25-NH2]insulin(human)

G P Schwartz et al. Proc Natl Acad Sci U S A. 1989 Jan.

Abstract

An insulin analogue that embodies two distinct structural modifications, each of which independently increases insulin activity, has been synthesized and evaluated for biological activity. The analogue, des-(B26-B30)-[AspB10,TyrB25-NH2]insulin is the most potent insulin analogue yet described; it displays an 11- to 13-fold higher activity than natural insulin. The findings are discussed with regard to the receptor-binding domains of insulin.

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