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Review
. 2015 Dec:59:1-15.
doi: 10.1016/j.neubiorev.2015.09.013. Epub 2015 Oct 1.

Translating depression biomarkers for improved targeted therapies

David S Bredt  1 , Maura L Furey  2 , Guang Chen  2 , Tim Lovenberg  2 , Wayne C Drevets  3 , Husseini K Manji  3
Affiliations
Review

Translating depression biomarkers for improved targeted therapies

David S Bredt et al. Neurosci Biobehav Rev. 2015 Dec.

Abstract

Mood disorders are among the most common medical conditions and cause amongst the greatest disease burden. Currently approved antidepressants target monoamine pathways; these medicines take many weeks to relieve symptoms, and most patients do not have sustained responses. This review will highlight recent advances in translational science identifying dysfunctional biochemical processes and neuronal circuits associated with mood disorders. We will also summarize strategies for targeting these pathways and for enhancing synaptic plasticity to develop most effective and rapidly acting antidepressant therapies.

Keywords: Biomarker; Bipolar; Depression; Glutamate; Imaging; Mood; Neuropharmacology; Synaptic plasticity.

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