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. 2015 Aug;10(8):1353-4.

A New C23 Steroid from the Venom of Bufo bufo gargarizans

Shi-Lin Luo, Hai-Yan Tian, Jun-Shan Liu, Ying Wang, Wen-Cai Ye
  • PMID: 26434114

A New C23 Steroid from the Venom of Bufo bufo gargarizans

Shi-Lin Luo et al. Nat Prod Commun. 2015 Aug.

Abstract

A new C23 steroid, (3β,5β,14β)-methyl (3-hydroxy-14,15-epoxy-20-oxo-21-norcholan-24-oate) (1), together with four known ones (2-5), were isolated from the venom of Bufo bufo gargarizans. Their structures were elucidated on the basis of extensive spectroscopic analysis. The cytotoxicity of these compounds was also evaluated against human hepatocarcinoma HepG2 cells. Compound 3 showed significant cytotoxicity with an IC50 value of 16.8 +/- 0.7 μM.

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