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. 2015 Dec 7;51(94):16832-5.
doi: 10.1039/c5cc07022h.

Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser

Jordan Atchison  1 , Sukanta Kamila  1 , Conor McEwan  1 , Heather Nesbitt  1 , James Davis  2 , Colin Fowley  1 , Bridgeen Callan  1 , Anthony P McHale  1 , John F Callan  1
Affiliations

Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser

Jordan Atchison et al. Chem Commun (Camb). .

Abstract

A new sensitiser (4) for use in photodynamic therapy (PDT) has been developed to enable control of ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer (BxPC-3) tumours.

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