Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Aug;9(8):OD03-4.
doi: 10.7860/JCDR/2015/13465.6329. Epub 2015 Aug 1.

Paroxysmal Nocturnal Haemoglobinuria Masquerading as Malaria: A Case Report

Archana Dambal  1 , Naren V Nimbal  2 , Shanmukh T Kalsad  3 , K Pramod  4 , M P Madhavaranga  5
Affiliations
Case Reports

Paroxysmal Nocturnal Haemoglobinuria Masquerading as Malaria: A Case Report

Archana Dambal et al. J Clin Diagn Res. 2015 Aug.

Abstract

Paroxysmal Nocturnal Haemoglobinuria (PNH) is a rare type of acquired Haemolytic anaemia that is described as a triad of acquired intravascular Haemolysis, venous thrombosis and anaemia with pancytopenia sometimes due to bone marrow failure. However the classical triad may not be observed at once and fever due to leucocytopenia may confuse the clinical picture. Since this is a rare disease, other epidemiologically common causes may be attributed to the illness. We report a case of PNH with a rare association of malaria due to Falciparum and Vivax species which was undiagnosed for 6 years in a young man.

Keywords: Anaemia; CD55; CD59.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Lucio Luzzatto. Haemolytic Anaemia & Anaemia due to Acute Blood Loss. In: Dan L. Longo, Anthony S. Fauci et al (eds) Harrison’s” PRINCIPLES OF INTERNAL MEDICINE. (18th ed) 2012;vol 1:883–85.
    1. Castro-Gomes T, Mourão LC, Melo GC, Monteiro WM, Lacerda MV, et al. Potential immune mechanisms associated with anaemia in Plasmodium vivax malaria: a puzzling question. Infect Immun. 2014;82(10):3990–4000. - PMC - PubMed
    1. Marti M, Baum J, Rug M, Tilley L, Cowman AF. Signal-mediated export of proteins from the malaria parasite to the host erythrocyte. J Cell Biol. 2005;171(4):587–92. - PMC - PubMed
    1. Waitumbi JN, Opollo MO, Muga RO, Misore AO, Stoute JA. Red cell surface changes and erythrophagocytosis in children with severe plasmodium falciparum anaemia. Blood. 2000;95(4):1481–86. - PubMed
    1. Odhiambo CO, Otieno W, Adhiambo C, Odera MM, Stoute JA. Increased deposition of C3b on red cells with low CR1 and CD55 in a malaria-endemic region of western Kenya: implications for the development of severe anaemia. BMC Med. 2008;6:23. - PMC - PubMed

Publication types

LinkOut - more resources