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. 2015 Oct 28;137(42):13476-9.
doi: 10.1021/jacs.5b08734. Epub 2015 Oct 15.

Enantioselective 1,2-Difunctionalization of Dienes Enabled by Chiral Palladium Complex-Catalyzed Cascade Arylation/Allylic Alkylation Reaction

Xiang Wu  1 , Hua-Chen Lin  1 , Ming-Li Li  1 , Lu-Lu Li  1 , Zhi-Yong Han  1 , Liu-Zhu Gong  1   2
Affiliations

Enantioselective 1,2-Difunctionalization of Dienes Enabled by Chiral Palladium Complex-Catalyzed Cascade Arylation/Allylic Alkylation Reaction

Xiang Wu et al. J Am Chem Soc. .

Abstract

A Pd-catalyzed highly enantioselective three-component coupling of 1,3-dienes with aryl iodines and sodium dialkyl malonates has been successfully established by using a H8-BINOL-based phosphoramidite ligand. This reaction proceeded via a Pd-catalyzed cascade arylation and asymmetric allylic alkylation reaction, providing an efficient strategy for the enantioselective 1,2-difunctionalization of 1,3-dienes.

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